Gypseous soils have special properties that are different from other types of soil such as they suffer from large deformation when subjected to the environmental condition change such as wetting. Nano-silica is now being used as an additive in geotechnical engineering to enhance the geotechnical properties of soils. This study provides a comprehensive overview of the characteristics of nano-silica and its impact on preventing salt from dissolving and enhancing the bonding of gypseous soil containing high gypsum content of 80.4%. The durability tests (aging, wetting-drying cycles, and freezing-thawing cycles) conducted on gypseous soil samples before and after treatment with several ratios of nano-silica (1, 2, 3, 4, and 5%). The durability of treatment evaluated by conducting unconfined compression tests. Unconfined compression tests are conducted after 0, 7, 14, 21, and 28 days of aging period, 0, 1, 3, 6, 12, and 24 cycles of both wetting-drying and freezing-thawing cycles. The results showed that the cohesion of soil increases with age progressive by (33.35-57.42) %. Adding 1 and 2% of nano-silica to improve the geotechnical properties of gypseous soil is not sufficient, while 4 and 5% are optimum percentages. The cohesion of soil decreases with increasing the number of wetting-drying and freezing-thawing cycles by (6-100) % and (15-100) %, respectively.